PURPOSE: To obtain a bone resorption suppressing agent exhibiting excellent bone resorption suppressing action, free from side effect such as estrogen action and useful for the remedy of osteoporosis by using an estradiol derivative as an active component.
CONSTITUTION: The objective agent can be prepared by using an estradiol derivative of formula (R1 is H, alkyl or acyl; R2 is H, alkyl or alkynyl; R3 is alkyl, alkenyl, alkynyl or hydrocarbon group; R4 is H or hydrocarbon group; etc.), its salt or its ester as an active component, properly adding pharmacologically permissible conventional additives and forming in the form of a drug preparation by conventional process. It can be used in the form of tablet, pill, granule, powder, capsule, syrup, emulsion, suspension, etc. It is administered at a daily dose of 0.01-30mg for adult in 1-3 divided doses.
KUMAZUKI TAKAMARU
YAMAZAKI IWAO
GOTO GIICHI
