To easily and inexpensively ensure bone substitute at a defective part at a bone of a human body.
In a pseudo body liquid 2 adjusted to an original component, β-TCP is settled by discharging in liquid. When the supernatant of the slurry of β-TCP is removed, β-TCP of the slurry which is alkali of PH 11 etc is generated. It is added with collagen solution treated with hydrochloric acid and mixed, thereby curing is started by neutralization reaction. Finally, compound material of hydroxyapatite is formed in the state of agar to obtain the bone anaplerotic material. Curing occurs early only by β-TCP obtained by polymerization reaction of phosphoric acid, and hydrogen bond of collagen, and uniform bone replenishment is realized by utilizing β-TCP. In addition. Since the bone substitute is easily cured even when including water, anaplerosis is possible even at a bleeding site, and the material can be utilized also as the carrier of another drug.
SHIBATA AKIRA
FUJIWARA KIYOHIRO
JPH05285213A | 1993-11-02 | |||
JPH05285212A | 1993-11-02 | |||
JPH0464362A | 1992-02-28 | |||
JP2003111831A | 2003-04-15 | |||
JP2003038635A | 2003-02-12 | |||
JP2001137328A | 2001-05-22 |