Title:
低下した反応源性を有するＬＰＳを含むボルデテラワクチン
Document Type and Number:
Japanese Patent JP7311227
Kind Code:
B2
Abstract:
The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetella cell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.
Inventors:
Vanderley, Peter Andre
Arenas Bousteau, Jesus Andres
Pupo Escalona, Elder
Thomassen, Johannes Petrus Maria
Arenas Bousteau, Jesus Andres
Pupo Escalona, Elder
Thomassen, Johannes Petrus Maria
Application Number:
JP2019547272A
Publication Date:
July 19, 2023
Filing Date:
March 13, 2018
Export Citation:
Assignee:
Intravac Bee Buoy.
International Classes:
C08B37/00
Foreign References:
| CN108395458A |
Other References:
Carbohydrate Research,2013年,378,56-62
Scientific Reports ,2016年,6,25905 (1-17)
Scientific Reports ,2016年,6,25905 (1-17)
Attorney, Agent or Firm:
Ikeda Adult
Nomura Risa
Junichiro Sakamaki
Masakazu Noda
Nomura Risa
Junichiro Sakamaki
Masakazu Noda