Title:
ホウ素含有葉酸誘導体
Document Type and Number:
Japanese Patent JP7154528
Kind Code:
B2
Abstract:
To provide a new boron agent that allows a boron neutron capture therapy even for a BPA insusceptible cancer patient.SOLUTION: The present invention provides a boron-containing amino acid derivative represented by the following general formula (I) [R does not exist or denotes an amino acid residue, L denotes a linker, X denotes a group induced from a water-soluble boron cluster containingB], or a boron-containing amino acid derivative represented by the following general formula (II) [Ra denotes an amino acid residue, L does not exist or denotes a linker, X denotes a group induced from a water-soluble boron cluster containingB]. There is also provided a composition for boron neutron capture therapy containing the derivative.SELECTED DRAWING: None
Inventors:
Hiroyuki Nakamura
Application Number:
JP2017162387A
Publication Date:
October 18, 2022
Filing Date:
August 25, 2017
Export Citation:
Assignee:
National University Corporation Tokyo Institute of Technology
Stella Pharma Corporation
Stella Pharma Corporation
International Classes:
C07F5/05; A61K31/69; A61K41/00; A61P35/00
Domestic Patent References:
| JP2009504732A |
Foreign References:
| WO2017026276A1 |
Other References:
I.B.Sivaev et al,Derivatives of the closo-dodecaborate anion and their application in medicine,Russian Chemical Bulletin,2002年,51,1362-1374
Agarwal, Hitesh K. et al.,Synthesis of closo-1,7-carboranyl alkyl amines,Tetrahedron Letters,2011年,52(43),5664-5667
Gruzdev, D. A. et al.,Synthesis of novel carboranyl derivatives of α-amino acids,Russian Chemical Bulletin,2010年,59(1),110-115
Wu, Ye; Quintana, William,Coupling of Amino Carboranes to Carboxylic Acid Containing Substrates,Inorganic Chemistry,1999年,38(9),2025-2029
Hattori, Yoshihide et al.,A novel modification method of peptides and proteins by anionic dodecaborate cage in water,Peptide Science ,2011年,48th,47
Neirynck, P. et al.,Carborane-β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces,Journal of Materials Chemistry B: Materials for Biology and Medicine ,2015年,3(4),539-545
Agarwal, Hitesh K. et al.,Synthesis of closo-1,7-carboranyl alkyl amines,Tetrahedron Letters,2011年,52(43),5664-5667
Gruzdev, D. A. et al.,Synthesis of novel carboranyl derivatives of α-amino acids,Russian Chemical Bulletin,2010年,59(1),110-115
Wu, Ye; Quintana, William,Coupling of Amino Carboranes to Carboxylic Acid Containing Substrates,Inorganic Chemistry,1999年,38(9),2025-2029
Hattori, Yoshihide et al.,A novel modification method of peptides and proteins by anionic dodecaborate cage in water,Peptide Science ,2011年,48th,47
Neirynck, P. et al.,Carborane-β-cyclodextrin complexes as a supramolecular connector for bioactive surfaces,Journal of Materials Chemistry B: Materials for Biology and Medicine ,2015年,3(4),539-545
Attorney, Agent or Firm:
Kenichi Nomura
Mayama Setuko
Mayama Setuko