Title:
BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF
Document Type and Number:
Japanese Patent JP2014169317
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide novel boronate ester compounds useful as proteasome inhibitors, pharmaceutical compositions comprising the novel compounds, and methods of using the compositions in the treatment of various diseases.SOLUTION: Novel compounds useful as proteasome inhibitors are represented by compounds of the formula (I-1). The compounds of the formula (I-1) form pharmaceutical compositions comprising crystalline forms of the compounds, fillers, and optional lubricants. These are suitable for producing pharmaceutical dosage forms of lyophilized powder.
Inventors:
ERIC L ELLIOTT
ABU J FERDOUS
MICHAEL J KAUFMAN
SONJA A KOMAR
DEBRA L MAZAIK
QUENTIN J MCCUBBIN
PHUONG M NGUYEN
VAITHIANATHAN PALANIAPPAN
RAYMOND D SKWIERCZYNSKI
NOBEL T TRUONG
CSANAD M VARGA
PETER N ZAWANEH
ABU J FERDOUS
MICHAEL J KAUFMAN
SONJA A KOMAR
DEBRA L MAZAIK
QUENTIN J MCCUBBIN
PHUONG M NGUYEN
VAITHIANATHAN PALANIAPPAN
RAYMOND D SKWIERCZYNSKI
NOBEL T TRUONG
CSANAD M VARGA
PETER N ZAWANEH
Application Number:
JP2014103398A
Publication Date:
September 18, 2014
Filing Date:
May 19, 2014
Export Citation:
Assignee:
MILLENNIUM PHARM INC
International Classes:
C07F5/02; A61K9/08; A61K9/19; A61K9/48; A61K31/69; A61K47/02; A61K47/12; A61K47/14; A61K47/18; A61K47/26; A61K47/36; A61K47/38; A61K47/46; A61P35/00
Domestic Patent References:
| JP2004517931A | 2004-06-17 | |||
| JP5261488B2 | 2013-08-14 | |||
| JPH0556380B2 | 1993-08-19 | |||
| JP2014144981A | 2014-08-14 | |||
| JP2014196310A | 2014-10-16 | |||
| JP2014169316A | 2014-09-18 | |||
| JP2002145848A | 2002-05-22 |
Foreign References:
| WO2008027273A2 | 2008-03-06 |
Other References:
TETRAHEDRON, vol. 60, no. 49, JPN6016011677, 2004, pages 11175 - 11190, ISSN: 0003289855
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita