Title:
両末端ＰＥＧ化インテグリン結合性ペプチドおよびその使用方法
Document Type and Number:
Japanese Patent JP6789823
Kind Code:
B2
Abstract:
The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy.
Inventors:
Haus Nurse Ben H.
Sutcliff Julie L.
Sutcliff Julie L.
Application Number:
JP2016563034A
Publication Date:
November 25, 2020
Filing Date:
April 14, 2015
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C07K19/00; A61K31/337; A61K31/7068; A61K38/10; A61K38/19; A61K47/59; A61K47/64; A61K49/12; A61K49/14; A61K51/06; A61P11/00; A61P17/02; A61P35/00; A61P37/02; C07K7/00
Domestic Patent References:
| JP2013544248A | ||||
| JP2009509562A |
Foreign References:
| WO2012126441A1 |
Other References:
HAUSNER et al.,Cancer Research,2009, Vol.69,pp.5843-5850
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto