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Title:
HMGB1のBox-AおよびHMGB1のBox-A変異体のポリマー複合体
Document Type and Number:
Japanese Patent JP2010503630
Kind Code:
A
Abstract:
The present invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A. Further, the invention relates to novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A). Moreover, the present invention concerns the use of said polymer conjugates of polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and/or associated with an increased expression of RAGE.

Inventors:
Silvio Traversa
Chiara Lorenzette
Valentina Mainero
Sebastiano Morena
Silvano Fumello
Luca Beccaria
Application Number:
JP2009527748A
Publication Date:
February 04, 2010
Filing Date:
September 14, 2007
Export Citation:
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Assignee:
Claire Bliss Therapeutics SP
International Classes:
C07K14/47; A61K38/00; A61K45/00; A61K47/48; A61L27/00; A61L31/00; A61L33/00; A61P3/00; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P13/12; A61P15/00; A61P15/08; A61P17/00; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P31/12; A61P35/00; A61P37/06; A61P37/08; A61P39/02; A61P43/00; C07K19/00
Domestic Patent References:
JPS62503171A1987-12-17
JP2008511300A2008-04-17
JP2006510619A2006-03-30
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro