Title:
【発明の名称】ブラジキニンアンタゴニスト
Document Type and Number:
Japanese Patent JP2002517461
Kind Code:
A
Abstract:
Disclosed are multibinding compounds which are bradykinin antagonists. The multibinding compounds of this invention contain from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a bradykinin antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as cancer, pain, shock, asthma, rhinitis, arthritis, inflammatory bowel disease, and the like.
Inventors:
Christensen, Burton Gee.
Natarajan, Maya
Griffin, John H.
Natarajan, Maya
Griffin, John H.
Application Number:
JP2000553107A
Publication Date:
June 18, 2002
Filing Date:
June 07, 1999
Export Citation:
Assignee:
Advanced Medicine Incorporated
International Classes:
G01N33/53; A61K31/00; A61K31/4184; A61K31/437; A61K31/4439; A61K31/444; A61K31/47; A61K31/4709; A61K31/496; A61K31/498; A61K38/00; A61K39/00; A61K39/395; A61K39/44; A61K51/00; A61P1/04; A61P9/02; A61P11/06; A61P19/02; A61P25/04; A61P27/16; A61P35/00; A61P43/00; C07D211/90; C07D215/24; C07D235/26; C07D241/42; C07D471/04; C07K2/00; C07K4/00; G01N33/543; G01N33/566; (IPC1-7): C07D215/24; A61K31/4184; A61K31/437; A61K31/4439; A61K31/444; A61K31/47; A61K31/4709; A61K31/496; A61K31/498; A61K38/00; A61P1/04; A61P9/02; A61P11/06; A61P19/02; A61P25/04; A61P27/16; A61P35/00; A61P43/00; C07D211/90; C07D235/26; C07D241/42; C07D471/04; G01N33/53; G01N33/543; G01N33/566
Attorney, Agent or Firm:
Shusaku Yamamoto