Title:
【発明の名称】セフエム誘導体の製造法
Document Type and Number:
Japanese Patent JP3195371
Kind Code:
B2
Abstract:
The present invention provides a process for preparing a cephem derivative characterized in that an allenyl beta -lactam compound represented by the formula (1) wherein R<1> is amino or protected amino, R<2> is a hydrogen atom or lower alkoxyl, R<3> is a hydrogen atom or carboxylic acid protecting group and X is the group -SO2R<4> or -SR<4>, R<4> being substituted or unsubstituted aryl or substituted or unsubstituted nitrogen-containing aromatic heterocyclic group is reacted with a nucleophilic agent to obtain the derivative, the cephem derivative being represented by the formula (2) wherein R<1>, R<2> and R<3> are as defined above, and Y is the residue of the nucleophilic agent.
Inventors:
Shigeru Torii
Hideo Tanaka
Masatoshi Taniguchi
Michio Sasaoka
Takashi Kii
Yutaka Kameyama
Hideo Tanaka
Masatoshi Taniguchi
Michio Sasaoka
Takashi Kii
Yutaka Kameyama
Application Number:
JP7245091A
Publication Date:
August 06, 2001
Filing Date:
March 11, 1991
Export Citation:
Assignee:
Otsuka Chemical Co., Ltd.
International Classes:
C07D501/00; C07D501/08; C07D501/59; (IPC1-7): C07D501/08; C07D501/59
Domestic Patent References:
| JP4981384A | ||||
| JP3255066A | ||||
| JP347084A | ||||
| JP4211055A | ||||
| JP5257188A | ||||
| JP51105051A | ||||
| JP51105088A | ||||
| JP5257162A | ||||
| JP50129590A | ||||
| JP5214789A |
Other References:
Ｃｈｅｍ．Ｌｅｔｔ．，Ｎｏ．１０（１９９０），ｐｐ．１８６７−１８６８
Attorney, Agent or Firm:
Iwao Tamura