Title:
架橋型核酸ＧｕＮＡ、その製造方法および中間体化合物
Document Type and Number:
Japanese Patent JP6994197
Kind Code:
B2
Abstract:
The present invention provides a method for preparing intermediate compounds for producing guanidine crosslinked artificial nucleic acid (abbreviated hereinafter as GuNA), and an intermediate compound for the production thereof. Specifically, the present invention provides a method for producing a compound represented by general formula VIII: (in the formula, R3, R4, R5, R6, R12, R13, m and B are as defined in the specification) or a salt thereof, the method comprising a step of substituting a cycle A in a compound represented by a general formula IX. (in the formula, R3, R4, R5, R6, R14, R15, m, and ring A are as defined in the specification).
Inventors:
Satoshi Kobiga
Eiji Kawanishi
Hiroaki Sawamoto
Shuhei Yamakoshi
Yuki Arai
Shinji Kumagai
Eiji Kawanishi
Hiroaki Sawamoto
Shuhei Yamakoshi
Yuki Arai
Shinji Kumagai
Application Number:
JP2017540049A
Publication Date:
January 14, 2022
Filing Date:
September 20, 2016
Export Citation:
Assignee:
Mitsubishi Tanabe Pharma Corporation
National University Corporation Osaka University
National University Corporation Osaka University
International Classes:
C07H19/067; A61K31/7088; A61K48/00; C07H9/06; C07H19/10; C07H19/16
Domestic Patent References:
| JP9328497A | ||||
| JP2002521310A |
Foreign References:
| WO2016145142A1 | ||||
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| WO2014124952A1 | ||||
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| WO1998039352A1 | ||||
| WO2005021570A1 | ||||
| WO2016100569A1 |
Other References:
BARMAN,J. et al,RSC ADV.,2015年,Vol.5,pp.12257-12260
SHRESTHA,A.R. et al,CHEM.COMMUN.,2014年,Vol.50,pp.575-577
MADSEN,A.S. et al,J.ORG.CHEM.,2012年,Vol.77,pp.10718-10728
HANESSIAN,S. et al,J.ORG.CHEM.,2013年,Vol.78,pp.9064-9075
KITANO,K. et al,TETRAHEDRON,1997年,Vol.53, No.39,pp.13315-13322
SALINAS,J.C. et al,J.ORG.CHEM.,2014年,Vol.79,pp.11651-11660
SHRESTHA,A.R. et al,CHEM.COMMUN.,2014年,Vol.50,pp.575-577
MADSEN,A.S. et al,J.ORG.CHEM.,2012年,Vol.77,pp.10718-10728
HANESSIAN,S. et al,J.ORG.CHEM.,2013年,Vol.78,pp.9064-9075
KITANO,K. et al,TETRAHEDRON,1997年,Vol.53, No.39,pp.13315-13322
SALINAS,J.C. et al,J.ORG.CHEM.,2014年,Vol.79,pp.11651-11660
Attorney, Agent or Firm:
Mutsumi Samejima
Sei Morimoto
Nobuhiko Akiyama
Sei Morimoto
Nobuhiko Akiyama