Title:
C-19 steroid for remedial use
Document Type and Number:
Japanese Patent JP6025301
Kind Code:
B2
Abstract:
The present invention relates to novel uses of C-19 steroid compounds, in particular C-19 steroids having an androsten-17-(OR 4 )-3-one structure for prophylactic and/or therapeutic uses, wherein R 4 is hydrogen or an unsubstituted or substituted alkyl, aryl, acyl or any group leading to hydroxyl upon biological metabolization or chemical deprotection. The present invention particularly relates to selected C-19 steroids displaying properties of high binding affinity to androgen receptor to block dihydotestosterone from binding, while at the same time providing anabolic effects, which is useful for certain applicationsThe therapeutic applications particularly include concepts based on influencing or controlling collagen and related therapeutic aspects, as well as concepts making use of certain disclosed effects the mentioned C-19 steroid compounds based on blocking the androgen receptor (AR) against binding of the natural androgen, dihydrotestosterone (DHT), while primarily circumventing a direct aromatase-inhibiting effect, The present invention also describes a pharmaceutical composition comprising a combination of such a compound and dimethyl isosorbide.
Inventors:
Martin Windish
Application Number:
JP2010533487A
Publication Date:
November 16, 2016
Filing Date:
November 12, 2008
Export Citation:
Assignee:
PROCIMA GMBH
International Classes:
A61K31/568; A61P5/24; A61P13/08; C07J1/00
Domestic Patent References:
| JP2003519182A | ||||
| JP2003534279A |
Foreign References:
| US20030229063 |
Attorney, Agent or Firm:
Akira Shimoda
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