Title:
C-ニトロソ化合物とその使用
Document Type and Number:
Japanese Patent JP2004512318
Kind Code:
A
Abstract:
A C-nitroso compound having a molecular weight ranging from about 225 to about 1,000 (from about 225 to about 600 for oral administration) on a monomeric basis wherein a nitroso group is attached to a tertiary carbon, which is obtained by nitrosylation of a carbon acid having a pKa less than about 25, is useful as an NO donor. When the compound is obtained from a carbon acid with a pKa less than about 10, it provides vascular relaxing effect when used at micromolar concentrations and this activity is potentiated by glutathione to be obtained at nanomolar concentrations. When the compound is obtained from a carbon acid with a pKa ranging from about 15 to about 20, vascular relaxing effect is obtained at nanomolar concentrations without glutathione. The compound is preferably water-soluble and preferably contains a carbon alpha to the nitrosylated carbon which is part of a ketone group. In one embodiment, the C-nitroso compound is obtained by nitrosylation of a conventional drug or such drug modified to modify the carbon acid pKa thereof. When such drug is a nonsteroidal anti-inflammatory drug, the resulting C-nitroso compound functions as a COX-1 and COX-2 inhibitor without the deleterious effects associated with COX-1 inhibition but with the advantageous effects associated with COX-1 and COX-2 inhibition. One such C-nitroso compound is a nitrosoketoibuprofen. A specific example of this kind of compound is isolated as dimeric 2-[4'-(alpha-nitroso)isobutyrylphenyl]propionic acid. In another case, the C-nitroso compound contains the moiety where X is S, O or NR. One embodiment is directed to COX-2 inhibitors where a tertiary carbon atom and/or an oxygen atom and/or a sulfur atom is nitrosylated.
Inventors:
Jonathan S. Stamler
Eric Jay Toon
Eric Jay Toon
Application Number:
JP2002537699A
Publication Date:
April 22, 2004
Filing Date:
September 27, 2001
Export Citation:
Assignee:
DUKE UNIVERSITY
International Classes:
A61K31/00; A61K31/194; A61K31/195; A61K31/222; A61K31/553; A61K31/635; A61K38/00; A61L27/00; A61L31/00; A61P7/02; A61P9/10; A61P29/00; A61P31/04; A61P31/12; C07C207/00; C07C291/08; C07D231/12; C07D267/04; (IPC1-7): C07C207/00; A61K31/194; A61K31/222; A61K31/553; A61K31/635; A61K38/00; A61L27/00; A61L31/00; A61P7/02; A61P9/10; A61P29/00; A61P31/04; A61P31/12; C07C291/08; C07D231/12; C07D267/04
Foreign References:
| WO2000025776A1 | 2000-05-11 |
Other References:
JPN6011033643; Ｋｌａｕｓ Ｒｅｈｓｅ ａｎｄ Ｍａｒｔｉｎ Ｈｅｒｐｅｌ: 'Ａｚｏｄｉｏｘｉｄｅｓ Ａｃｔｉｖａｔｅｄ ｂｙ Ｅｌｅｃｔｒｏｎ Ａｃｃｅｐｔｏｒｓ ｉｎ Ｇｅｍｉｎａｌ ｏｒ Ｖｉｃｉｎａｌ Ｐｏｓｉｔｉｏｎ' Ａｒｃｈ． Ｐｈａｒｍ． Ｐｈａｒｍ． Ｍｅｄ． Ｃｈｅｍ． Ｖｏｌ．３３１, 1998, ｐ．１０４-１１０
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima