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Title:
C20-C21置換グルココルチコイド受容体アゴニスト
Document Type and Number:
Japanese Patent JP2011507878
Kind Code:
A
Abstract:
The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and as defined herein. The present invention also provides compounds (and salts, solvates, esters, prodrugs, tautomers, and isomers) of Formulas II, III, IV, V, and VI, as defined herein. Also provided are pharmaceutical compositions, methods of preparing, and methods of using such compounds in the treatment and prophylaxis of a wide range of immune, autoimmune, and inflammatory diseases and conditions.

Inventors:
Antes, John Sea.
McCormick, Kevin Dee.
Hey, John A.
Aslanian, Robert G.
Biju, Praccat Le Jay.
Berlin, Michael Wye.
Solomon, Daniel M.
One, Hong Woo
Rim, Yong-hee
Lee, Yun Cho
Bitter, Rema Daniel
Application Number:
JP2010539762A
Publication Date:
March 10, 2011
Filing Date:
December 18, 2008
Export Citation:
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Assignee:
Schering Corporation
International Classes:
C07J3/00; A61K31/57; A61K31/573; A61K31/58; A61P1/00; A61P11/00; A61P11/06; A61P17/00; A61P27/02; A61P29/00; A61P37/00; A61P37/08; A61P43/00; C07J5/00; C07J17/00; C07J21/00; C07J43/00
Domestic Patent References:
JP2004505990A2004-02-26
JPS54141758A1979-11-05
JPH08501804A1996-02-27
JPS63500868A1988-03-31
JP2008546694A2008-12-25
JP2011507879A2011-03-10
Foreign References:
GB1119082B
WO2002036606A12002-05-10
US3598816A1971-08-10
GB1302572B
US3020275A1962-02-06
GB954146B
Other References:
JPN6013038014; Journal of Steroid Biochemistry 33(4A), 1989, 557-563
JPN6013038001; 薬学雑誌 109(3), 1989, 195-198
JPN6013038003; Journal of Pharmaceutical and Biomedical Analysis 17, 1998, 1029-1036
JPN6013038005; Biochemistry 18(22), 1979, 4915-4922
JPN6013038007; Chemical & Pharmaceutical Bulletin 37(7), 1989, 1795-1801
JPN6013038009; Chemical & Pharmaceutical Bulletin 37(12), 1989, 3286-3293
JPN6013038012; Journal of the Chemical Society 26, 1961, 5052-5054
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita