Title:
ＣＡＲ発現ベクター及びＣＡＲ発現Ｔ細胞
Document Type and Number:
Japanese Patent JP7300763
Kind Code:
B2
Abstract:
An object of the present invention is to provide CAR-expressing T cells that coexpress a chimeric antigen receptor (CAR) and a T cell immune function-enhancing factor and have a high immunity-inducing effect and antitumor activity, and to provide a CAR expression vector for the preparation of the CAR-expressing T cells. A CAR expression vector comprises a nucleic acid encoding a chimeric antigen receptor (CAR) and a nucleic acid encoding a T cell immune function-enhancing factor, wherein the nucleic acid encoding an immune function-enhancing factor is a nucleic acid encoding interleukin-7 and a nucleic acid encoding CCL19, a nucleic acid encoding a dominant negative mutant of SHP-1, or a nucleic acid encoding a dominant negative mutant of SHP-2, or a CAR-expressing T cell introduced with the CAR expression vector are prepared.
Inventors:
Koji Tamada
Yukimi Sakoda
Keishi Adachi
Yukimi Sakoda
Keishi Adachi
Application Number:
JP2021213604A
Publication Date:
June 30, 2023
Filing Date:
December 28, 2021
Export Citation:
Assignee:
Yamaguchi University
International Classes:
C12N15/63; A61K31/675; A61K31/7076; A61K35/17; A61P35/00
Domestic Patent References:
| JP2014504294A | ||||
| JP2014507118A |
Foreign References:
| WO2013123061A1 | ||||
| WO2013126729A1 |
Other References:
Front. Immunol.,2012年,Vol.3,article 285 (pp. 1-10)
J. Immunol.,1999年,Vol.162, No.10,pp. 5680-5684
臨床血液,2014年06月30日,Vol.55, No.6,pp. 651-656
Clin. Cancer Res.,2012年,Vol.18, No.23,pp. 6436-6445
Immunol. Rev.,2009年,Vol.228,pp. 342-359
J. Immunol.,1999年,Vol.162, No.10,pp. 5680-5684
臨床血液,2014年06月30日,Vol.55, No.6,pp. 651-656
Clin. Cancer Res.,2012年,Vol.18, No.23,pp. 6436-6445
Immunol. Rev.,2009年,Vol.228,pp. 342-359
Attorney, Agent or Firm:
Masaki Hirota
Yusaku Tokai
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Shohei Fujimoto
Yusaku Tokai
Makoto Horiuchi
Masako Yamauchi
Shuichi Sonomoto
Shohei Fujimoto