Title:
CXCR3ケモカイン受容体、抗体、核酸および使用方法
Document Type and Number:
Japanese Patent JP4502408
Kind Code:
B2
Abstract:
The present invention relates to recombinant mammalian (e.g., human) IP-10/Mig receptor proteins designated CXC Chemokine Receptor 3 (CXCR3) and variants thereof, including those characterized by selective binding of one or more chemokines (e.g., IP-10 and/or Mig), and/or the ability to induce a cellular response (e.g., chemotaxis, exocytosis). Another aspect of the invention relates to antisense nucleic acid, recombinant nucleic acid constructs, such as plasmids or retroviral vectors, methods of identifying ligands, and inhibitors (e.g., antagonists) or promoters (e.g., agonists) of receptor function.
Inventors:
Letcher, marcel
Moselle, Bernhard
Chin, shishin
McKay, Charles, Earl.
Moselle, Bernhard
Chin, shishin
McKay, Charles, Earl.
Application Number:
JP51377198A
Publication Date:
July 14, 2010
Filing Date:
September 10, 1997
Export Citation:
Assignee:
Theodor-Kocher Institute
International Classes:
C12N15/09; G01N33/50; A61K47/48; C07K14/19; C07K14/715; C07K16/18; C07K16/28; C12N5/10; C12N15/12; C12P21/08; G01N33/15; G01N33/53; A61K38/00
Domestic Patent References:
| JP8503463A |
Foreign References:
| WO1996022371A1 |
Other References:
Genomics, 1995年, vol.29, p.335-344
FEBS Lett, 1995年, vol.376, p.19-23
J. Exp. Med., 1996年 9月 1日, vol.184, no.3, p.963-969
FEBS Lett, 1995年, vol.376, p.19-23
J. Exp. Med., 1996年 9月 1日, vol.184, no.3, p.963-969
Attorney, Agent or Firm:
Yoshinori Hosoda