To provide a calcium phosphate-synthetic resin-metal composite having an excellent processability, biocompatibility and water resistance and not separated from a metal member, and its manufacturing method.

This manufacturing method for the calcium phosphate-synthetic resin-metal composite wherein the metal member 100 having a window 101 is filled with a calcium phosphate-synthetic resin composite 200 comprises a process (a) for treating a mixture consisting of calcium phosphate particles 300, at least partially crosslinked synthetic resin particles I and an uncrosslinked synthetic resin particles II under pressure and heating to obtain the calcium phosphate-synthetic resin composite 200, a process (b) for putting the calcium phosphate-synthetic resin composite 200 in a mold in the state fitted in the metal member 100 and a process (c) for treating the calcium phosphate-synthetic resin composite 200 under pressure and heating to expose the same from the window 101. The calcium phosphate-synthetic resin-metal composite wherein the synthetic resin particles are closely bonded to the calcium phosphate particles 200 and the metal member 100 and its manufacturing method are also disclosed.