Title:
カルシウム受容体活性化合物
Document Type and Number:
Japanese Patent JP4353985
Kind Code:
B2
Abstract:
Inorganic ion receptor modulating cpds. of formulae (I), (II) and (III) and their salts and complexes in the case of (I) and (II) are new, in which Ar2 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X1 ; X1 = lower alkyl, halo, lower alkoxy, lower thioalkyl, methylenedioxy, lower haloalkyl, lower haloalkoxy, OH, CH2OH, CONH2, CN or acetoxy; Ar1 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X2 ; X2 = as for X1 or N(CH3)2, phenyl, phenoxy, benzyl, benzyloxy, ~a,~a-dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl or ethylenedioxy; Ar3 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X3 ; X3 = as for X1 or benzyl, benzyloxy, dimethylbenzyl, NO2, CHO, CH3CH(OH), N(CH3)2, acetyl or ethylenedioxy; Ar4 = as for Ar2; Ar5 = naphthyl or phenyl which are opt. substd. with 0-5 substits. X4 ; X4 = as for X1 or benzyl, benzyloxy, ~a,~a-dimethylbenzyl, NO2, CHO, CH3CH(OH), acetyl, ethylenedioxy or -CH=CH-phenyl; Ar6= naphthyl or phenyl which are opt. substd. with 0-5 substits. X5 ; X5 = as for X1 or acetyl, carbomethoxy or OCH2C(O)C2H5; q = 0-3; R = H or lower alkyl; R9, R11, R12 = H or CH3; R8 = H or phenyl; R10 = H, CH3 or phenyl.
Inventors:
Van Weignen, Bradford See
Mow, Scott Tee
Ballandrin, Manuel F
Delmar, Eric G
Edward F, Nemes
Mow, Scott Tee
Ballandrin, Manuel F
Delmar, Eric G
Edward F, Nemes
Application Number:
JP2007042364A
Publication Date:
October 28, 2009
Filing Date:
February 22, 2007
Export Citation:
Assignee:
NPS PHARMACEUTICALS, INC.
International Classes:
C07C211/27; C07C211/30; A61K31/135; A61K31/137; A61K31/165; A61K31/215; A61K31/34; A61K31/343; A61K31/357; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61K31/445; A61K31/4468; A61P3/00; A61P3/14; A61P5/20; A61P9/08; A61P9/12; A61P13/12; A61P19/00; A61P19/08; A61P19/10; A61P35/00; A61P43/00; C07C211/28; C07C211/29; C07C211/31; C07C211/35; C07C211/38; C07C211/42; C07C215/08; C07C215/48; C07C217/16; C07C217/54; C07C217/56; C07C217/58; C07C217/60; C07C217/62; C07C219/28; C07C223/02; C07C225/16; C07C229/38; C07C255/58; C07C317/32; C07C323/32; C07D207/08; C07D207/323; C07D211/58; C07D215/14; C07D307/79; C07D317/58; C07D317/64; C07D319/18; C07D333/54; G01N33/566; G01N33/68
Domestic Patent References:
| JP2882882B2 |
Attorney, Agent or Firm:
Reiko Tanaka
Koji Morita
Koji Morita