Title:
CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES
Document Type and Number:
Japanese Patent JP2015061875
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug load significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF).SOLUTION: Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also disclosed. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also disclosed.
Inventors:
KUNTZ ARTHUR
MORAN JUSTIN KEITH
RUBINO JOSEPH THOMAS
JAIN NEERA
VIDUNAS EUGENE JOSEPH
SIMPSON JOHN MCLEAN
ROBBINS PAUL DAVID
MERCHANT NISHITH
DIJOSEPH JOHN FRANCIS
RUPPEN MARK EDWARD
DAMLE NITIN KRISHNAJI
POPPLEWELL ANDREW GEORGE
MORAN JUSTIN KEITH
RUBINO JOSEPH THOMAS
JAIN NEERA
VIDUNAS EUGENE JOSEPH
SIMPSON JOHN MCLEAN
ROBBINS PAUL DAVID
MERCHANT NISHITH
DIJOSEPH JOHN FRANCIS
RUPPEN MARK EDWARD
DAMLE NITIN KRISHNAJI
POPPLEWELL ANDREW GEORGE
Application Number:
JP2014256667A
Publication Date:
April 02, 2015
Filing Date:
December 18, 2014
Export Citation:
Assignee:
WYETH CORP
International Classes:
A61K39/395; A61K9/19; A61K41/00; A61K45/00; A61K47/26; A61K47/36; A61K47/38; A61K47/48; A61P35/00; A61P35/02; A61P43/00; C07K1/16; C07K16/28
Domestic Patent References:
| JPH11508232A | 1999-07-21 | |||
| JP2001518930A | 2001-10-16 | |||
| JP2000226336A | 2000-08-15 |
Foreign References:
| WO2001012653A1 | 2001-02-22 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Hiroshi Yamazaki
Kenji Tomita
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