Title:
癌の免疫療法
Document Type and Number:
Japanese Patent JP6772062
Kind Code:
B2
Abstract:
Immunogenic modulators and compositions comprising oligonucleotide agents capable of inhibiting suppression of immune response by reducing expression of one or more gene involved with an immune response suppression mechanism.
Inventors:
Wolfson Alexei
Eliseev Alexei
Sumshkovich Tysia
Eliseev Alexei
Sumshkovich Tysia
Application Number:
JP2016536769A
Publication Date:
October 21, 2020
Filing Date:
December 02, 2014
Export Citation:
Assignee:
Phio Pharmaceuticals Corp.
International Classes:
C12N15/113; A61K31/575; A61K31/7088; A61K31/713; A61K35/12; A61K35/15; A61K35/17; A61K35/28; A61K35/545; A61K48/00; A61P31/00; A61P35/00; A61P37/02; A61P43/00; C12N5/0783; C12N5/0784; C12N5/0789; C12N5/10
Foreign References:
| WO2012112079A1 |
Other References:
Borkner L. et al.,RNA interference targeting programmed death receptor-1 improves immune functions of tumor-specific T cells,Cancer Immunology, Immunotherapy,2010年,59(8),1173-1183
Peng S. et al.,Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life,Human Gene Therapy,2005年,16(5),584-593
Kim JH. et al.,Blocking the immunosuppressive axis with small interfering RNA targeting interleukin (IL)-10 receptor enhances dendritic cell-based vaccine potency,Clinical & Experimental Immunology,2011年,165(2),180-189
Peng S. et al.,Vaccination with dendritic cells transfected with BAK and BAX siRNA enhances antigen-specific immune responses by prolonging dendritic cell life,Human Gene Therapy,2005年,16(5),584-593
Kim JH. et al.,Blocking the immunosuppressive axis with small interfering RNA targeting interleukin (IL)-10 receptor enhances dendritic cell-based vaccine potency,Clinical & Experimental Immunology,2011年,165(2),180-189
Attorney, Agent or Firm:
Kiyoji Kuzuwa