CANNABINOID RECEPTOR MODULATOR

Title:

CANNABINOID RECEPTOR MODULATOR

Document Type and Number:

Japanese Patent JP2018021074

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide cannabinoid receptor modulators.SOLUTION: The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CBreceptor. The present invention further relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activities of both the CBreceptor and the CBreceptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pain, for example bone and joint pain, muscle pain, dental pain, headache pain, inflammatory pain, neuropathic pain, pain that occurs as an adverse effect of therapeutics and pain associated with osteoarthritis; hyperalgesia; allodynia; inflammatory hyperalgesia; neuropathic hyperalgesia; acute nociception; osteoporosis; multiple sclerosis-associated spasticity; autoimmune disorders; allergic reactions; CNS inflammation; atherosclerosis; undesired immune cell activity and inflammation; age-related macular degeneration; cough; leukemia; lymphoma; CNS tumors; prostate cancer; and Alzheimer's disease.SELECTED DRAWING: None

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Inventors:

JONES ROBERT M
HAN SANGDON
LARS THORESEN
JUNG JAE-KYU
SONJA STRAH-PLEYNET
ZHU XIUWEN
XIONG YIFENG
YUE DAWEI

Application Number:

JP2017207036A

Publication Date:

February 08, 2018

Filing Date:

October 26, 2017

Export Citation:

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Assignee:

ARENA PHARM INC

International Classes:

C07D231/54; A61K31/4184; A61K31/497; A61K31/675; A61P11/14; A61P13/08; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P25/28; A61P27/02; A61P35/00; A61P35/02; A61P37/02; A61P37/08; A61P43/00; C07D401/04; C07D401/14; C07D403/04; C07D405/14; C07F9/6558

Domestic Patent References:

JP5746698B2	2015-07-08
JP2005350457A	2005-12-22
JP2008508210A	2008-03-21

Foreign References:

WO2006129178A1	2006-12-07
WO2006069242A2	2006-06-29
WO2006030124A1	2006-03-23

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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