Title:
CARBA-2-PENEM COMPOUND AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5793981
Kind Code:
A
Abstract:
NEW MATERIAL:The compound of formulaI(R1 is alkyl, aryl, alkylthio, arylthio or acylaminoalkylthio; R2 and R3 are alkoxycarbonyl, cyano or COR1; R3 may be alkyl or aryl; R4 is H, alkyl, hydroxyalkyl, aryl, or amino), its salt and ester.
EXAMPLE: 1-Acetyl-1, 2-dimethyl-6-( 1-hydroxy-1-methylethyl )-carba-2-penem-3-carboxilic acid.
USE: Antibacterial agent. It is added to an animal feed, industrial water, etc. as a disinfectant.
PROCESS: The compound of formulaIcan be prepared by the cyclization of the compound of formula II (Z is phosphonio or phosphono) which is obtained from a novel compound of formula III. The compound of formula III is prepared by reacting the compound of formula IV with the compound of formula V.
Inventors:
MORIMOTO AKIRA
MIYAWAKI TOSHIO
YOSHIOKA KOUICHI
MIYAWAKI TOSHIO
YOSHIOKA KOUICHI
Application Number:
JP11498681A
Publication Date:
June 11, 1982
Filing Date:
July 21, 1981
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
A61K31/397; A61K31/40; A61P31/04; C07D205/08; C07D205/085; C07D205/09; C07D477/00; C07D477/26; C07F7/10; C07F9/568; (IPC1-7): A61K31/40; C07D205/08; C07D487/04