PURPOSE: To provide a novel compound having an excellent antibacterial action, stable in living bodies, and expressing internal kinetics.
CONSTITUTION: The compound of formula I [R1 is (substituted) 1-4C alkyl; COOR2 is (esterified)carboxyl; R3 is halogen; (substituted)hydroxyl, etc.; R6 is H, (substituted) 1-6C alkyl, etc.], and its salt. For example, (5S,6R,7R,11 R)-5-[(R)-1-hydroxyethyl]-11-[2-hydroxyethyl]-4-oxo-3,9- diazatricyclo[5.4.0.03'6]undeca-1-ene-2-carboxylic acid. The compound of formula I is produced e.g. by reacting a component of formula II with a compound of formula: P(R6)3(R6 is lower alkyloxy, lover alkyl, etc.) or a compound of formula: P(R6)2R6' (R6' is the same as R6) in an inert solvent or in a solvent-free state preferably at 80-140°C for 1-172hr and, if necessary, subsequently removing the protecting group from the reaction product.
NAGAI KATSUNORI
OKONOGI KENJI
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