Title:
CARBAPENEM COMPOUND
Document Type and Number:
Japanese Patent JPH04169584
Kind Code:
A
Abstract:
NEW MATERIAL:(5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a] [1,2,4]triazolium-6-yl) thio]-6-[(R)-l-hydroxyethyl]-carbapen-2-em-3-carboxylate.
USE: An antibacterial agent and β-lactamase inhibitor.
PREPARATION: The objective compound can be produced by reacting a compound of formula II (R1 is carboxy-protecting group; Ra is acyl) with a mercapto reagent of formula III (R6 is amino-protecting group), eliminating the protecting groups R1 and Rb from the obtained compound of formula VI and reacting the resultant compound of formula V with a formimidic acid ester derivative.
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Inventors:
HATANO TOSHIMITSU
ISODA TAKETOSHI
KUMAGAI TOSHIO
ISODA TAKETOSHI
KUMAGAI TOSHIO
Application Number:
JP29352090A
Publication Date:
June 17, 1992
Filing Date:
November 01, 1990
Export Citation:
Assignee:
LEDERLE JAPAN LTD
International Classes:
C07D477/00; A61K31/397; A61K31/40; A61P31/04; (IPC1-7): A61K31/40; C07D477/00
Attorney, Agent or Firm:
Heiyoshi Odashima (1 person outside)