CARBAPENEM DERIVATIVE, COMPOSITION AND MANUFACTURE

Title:

CARBAPENEM DERIVATIVE, COMPOSITION AND MANUFACTURE

Document Type and Number:

Japanese Patent JPS57146778

Kind Code:

A

Abstract:

A process for the preparation of an antibacterially active compound of the formula (I): (I) and salts and esters thereof wherein R1 and R2 independently are hydrogen or an organic group, and R3 is an organic group bonded via a carbon atom to the sulphur atom, which comprises reacting a compound of the formula (II): (II) wherein R4 is an organic group different to R3 and Ra is hydrogen or a carboxy-blocking group, with a thiol R3SH or reactive derivative thereof. In addition certain compounds within the formula (II) are novel and useful antibacterial agents in their own right.

Inventors:

DEIBITSUDO FURANSHISU KORUBITS
PAMIRA BURAUN
ROJIYAA JIYON PONSUFUOODO

Application Number:

JP1739382A

Publication Date:

September 10, 1982

Filing Date:

February 04, 1982

Export Citation:

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Assignee:

BEECHAM GROUP LTD

International Classes:

A61K31/397; A61K31/40; A61P31/04; C07D257/04; C07D477/02; C07D477/00; (IPC1-7): A61K31/40; A61K31/41; A61K31/415; A61K31/44; A61K31/505; A61K31/53; C07D487/04

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