Title:
CARBAPENEMS BONDED WITH ALKYLENE HETERO ATOM BRIDGE AND HAVING 2-POSITION SUBSTITUENT
Document Type and Number:
Japanese Patent JPS61191685
Kind Code:
A
Abstract:
Carbapenems having the formula: wherein R<3> is H; R<4> is a bridging group comprising substituted or unsubstituted C2-C4 straight, C2-C6 branched or C3-C7 cycloalkyl groups wherein the substituents are selected from C1-C6 alkyl, O-C1-C6 alkyl, S-C1-C6 alkyl, CF3, N(C1-C6 alkyl)2; R<1> and R<2> are independently H, CH3-, CH3CH2-, (CH3)2CH-HOCH2-, CH3CH(OH)-, (CH3)2C(OH)-, FCH2-, F2CH-, F3C-, CH3CH(F)-, (CH3)2C(F)-, or CH3CF2-; R<5> is unsubstituted or substituted aliphatic radical which can include heterocyclic and heteroarylium substituents; X is -S-, -SO-, -SO2-, -O-, or -NH; and W is a carboxy-containing group; their preparation and antibiotic use are disclosed.
Inventors:
TOOMASU ENU ZARUTSUMAN
BAATON JII KURISUTENSEN
JIEEMUSU BUI HETSUKU
BAATON JII KURISUTENSEN
JIEEMUSU BUI HETSUKU
Application Number:
JP27938285A
Publication Date:
August 26, 1986
Filing Date:
December 13, 1985
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
C07D477/00; A61K31/397; A61K31/40; A61P31/04; C07D477/14; C07F7/18; C07F9/568; (IPC1-7): A61K31/40; C07D487/04
Domestic Patent References:
| JPS56122379A | 1981-09-25 | |||
| JPS57144285A | 1982-09-06 | |||
| JPS58103388A | 1983-06-20 | |||
| JPS5936677A | 1984-02-28 |
Attorney, Agent or Firm:
Masao Okabe