Title:
CARBAPENEMS HAVING INNER OR OUTER ALKYLATED MONOCYCLIC OR BICYCLIC QUATERNARY HETEROARYL ALKYL HETEROMETHYL SUBSTITUENT IN 2-POSITION
Document Type and Number:
Japanese Patent JPS61155387
Kind Code:
A
Abstract:
Carbapenems having the formula:wherein:R1 is H;R4 and R5 are independently H, CH3-, CH3CH2-, (CH3)2CH-, HOCH2-, CH3CH(OH)-, (CH3)2C(OH)-, FCH2, F2CH-, F3C-, CH3CH(F)-, CH3CF2-, (CH3)2C(F)-;X is -S-, -SO-, -S02-, -O- or -NH;L is a bridging group comprising substituted or unsubstituted C1-C4 straight, C2-C6 branched or C3-C7 cycloalkyl groupswherein the substituents are selected from C1-C6 alkyl, O-C1-C6 alkyl, S-C1-C6 alkyl, CF3, N(C1-C6 alkyl)2;Y is a carboxy-containing substituent; Het is internally alkylated heteroarylium,or externally alkylated heteroarylium,their preparation and antibiotic use are disclosed.
Inventors:
BAATON JII KURISUTENSEN
JIEEMUSU BUI HETSUKU
RONARUDO DABURIYU RATOKURIFU
TOOMASU ENU ZARUTSUMAN
JIEEMUSU BUI HETSUKU
RONARUDO DABURIYU RATOKURIFU
TOOMASU ENU ZARUTSUMAN
Application Number:
JP27938185A
Publication Date:
July 15, 1986
Filing Date:
December 13, 1985
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/40; A61P31/04; C07D487/04; C07D477/14; (IPC1-7): A61K31/40; C07D487/04
Attorney, Agent or Firm:
Masao Okabe