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Title:
CARBONATE DERIVATIVE OF ESEROLINE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPH02289572
Kind Code:
A
Abstract:

NEW MATERIAL: Carbonate deriv. of eseroline of formula I (R is a lower alkyl, a cycloalkyl, an aryl, an aralkyl or formula II; X is H or a halogen) and acid addition salts thereof, and when isomers exist, their geometric and optical isomers and mixtures thereof.

EXAMPLE: 4-Chlorophenyl(3a,S-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8- trimethylpyrrolo[2,3-b]indol-5-il carbonate.

USE: They have an effect for relaxing pains of mammals and are useful as analgesics. Peroral administration can be performed.

PROCESS: A compd. of formula III is reacted with a carbonate of formula IV to obtain a compd. of formula I wherein X is H. In addition, after the compd. of formula III is reacted with 1,1-carbonyldiimidazole of formula V, a compd. which is a product of formula VI is reacted again offhand with the compd. of formula III to obtain a compd. of formula I wherein R is formula II.


Inventors:
EDOWAADO JIEI GURAMUKOUSUKII
YUURIN CHIAN
BAABARA II KARISU
Application Number:
JP7360390A
Publication Date:
November 29, 1990
Filing Date:
March 26, 1990
Export Citation:
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Assignee:
HOECHST ROUSSEL PHARMA
International Classes:
A61K31/40; A61P25/04; C07D487/04; C07D519/00; (IPC1-7): A61K31/40; C07D487/04
Domestic Patent References:
JPS54112897A1979-09-04
JPS6323881A1988-02-01
Attorney, Agent or Firm:
Chika Takagi (2 outside)