NEW MATERIAL: Carbonate deriv. of eseroline of formula I (R is a lower alkyl, a cycloalkyl, an aryl, an aralkyl or formula II; X is H or a halogen) and acid addition salts thereof, and when isomers exist, their geometric and optical isomers and mixtures thereof.
EXAMPLE: 4-Chlorophenyl(3a,S-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8- trimethylpyrrolo[2,3-b]indol-5-il carbonate.
USE: They have an effect for relaxing pains of mammals and are useful as analgesics. Peroral administration can be performed.
PROCESS: A compd. of formula III is reacted with a carbonate of formula IV to obtain a compd. of formula I wherein X is H. In addition, after the compd. of formula III is reacted with 1,1-carbonyldiimidazole of formula V, a compd. which is a product of formula VI is reacted again offhand with the compd. of formula III to obtain a compd. of formula I wherein R is formula II.
YUURIN CHIAN
BAABARA II KARISU
| JPS54112897A | 1979-09-04 | |||
| JPS6323881A | 1988-02-01 |