Title:
カルボン酸アミド、その調製法及び医薬組成物としてのその使用
Document Type and Number:
Japanese Patent JP3853653
Kind Code:
B2
Abstract:
The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1 , the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
Inventors:
Lies Uwe
Prepke Henning
Heckel Armin
Naru Herbert
Wienen Wolfgang
Stassen Yarn Marie
Prepke Henning
Heckel Armin
Naru Herbert
Wienen Wolfgang
Stassen Yarn Marie
Application Number:
JP2001515290A
Publication Date:
December 06, 2006
Filing Date:
August 02, 2000
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft
International Classes:
C07C257/18; C07D295/18; A61K31/167; A61K31/18; A61K31/40; A61K31/4164; A61K31/4453; A61P7/02; A61P43/00; C07C303/40; C07C311/21; C07C311/46; C07D207/12; C07D211/46; C07D213/68; C07D233/54; C07D295/12; C07D295/135; C07D295/185; C07D295/192
Domestic Patent References:
| JP4249551A | ||||
| JP1093568A |
Other References:
SAKAGUCHI,J. et al.,Chem. Pharm. Bull.,1992年,Vol.40, No.1,p.202-211
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda