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Title:
CARBOXYLIC ACID DERIVATIVE
Document Type and Number:
Japanese Patent JP2004277427
Kind Code:
A
Abstract:

To provide a carboxylic acid derivative exhibiting potent and selective cathepsin K inhibitory action and also useful for producing a cyclic amide derivative of a potential bone resorption inhibitor useful as a therapeutic agent for bone diseases such as osteoporosis.

The carboxylic acid derivative is represented by general formula (II). In general formula (II), ring A is a 5-7C saturated cyclic alkyl or a 3-6C saturated heterocycle containing a heteroatom, R1 is a substituted amide represented by the general formula, and R9 is phenyloxy, 2-methylpropyloxy, 3,4-methylenedioxyphenyl, morpholin-4-yl, N-tert-butyloxycarbonylpiperidin-4-yl, a piperazine derivative or a group represented by formula: R11-B.


Inventors:
HOSODA AKIHIKO
KOBAYASHI NOBUO
TANABE NAOKO
SHOJI TSUNEO
SHIBATA MASAHIRO
SEKINE AKIHIRO
MICHIYOSHI KIMIYOSHI
Application Number:
JP2004144158A
Publication Date:
October 07, 2004
Filing Date:
May 13, 2004
Export Citation:
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Assignee:
SEIKAGAKU KOGYO CO LTD
International Classes:
C07D295/20; A61K31/165; A61K31/18; A61K31/27; A61K31/36; A61K31/4406; A61K31/445; A61K31/47; A61K31/495; A61K31/5375; A61K31/5377; A61K31/54; A61K31/55; A61K31/551; A61P7/00; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P43/00; C07C271/24; C07C271/56; C07D211/46; C07D211/58; C07D211/62; C07D213/71; C07D213/75; C07D215/36; C07D223/12; C07D231/40; C07D277/20; C07D277/46; C07D277/82; C07D307/14; C07D307/33; C07D307/52; C07D309/20; C07D317/28; C07D317/46; C07D317/66; C07D317/68; C07D317/72; C07D319/06; (IPC1-7): C07C271/24; A61P7/00; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P43/00; C07C271/56; C07D211/46; C07D211/58; C07D211/62; C07D213/71; C07D213/75; C07D215/36; C07D223/12; C07D231/40; C07D277/20; C07D277/46; C07D277/82; C07D295/20; C07D307/14; C07D307/33; C07D307/52; C07D309/20; C07D317/28; C07D317/46; C07D317/66; C07D317/68; C07D317/72; C07D319/06
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda