NEW MATERIAL:A compound expressed by formula I [A is OH, alkoxy, formula II (Ra is H or alkyl; m is 0W2; R3 and R4 are alkyl or together cyclopentane ring, etc.) or formula III (Rb is H, halogen, carboxyl, amino, etc.); W is bonding group having 1W3 atom number, provided that O is not singly used; R1 and R2 are H, alkyl, phenyl, etc., or together formula IV (R5WR8 are H, halogen, carboxyl, alkyl, etc.)]. and salt thereof.
EXAMPLE: 3-N-{3-[2-[4-Isopropyl-2-thiazolyl)]ethenyl}benzoyl]amino-2-isobutyl- 2-methylpropionic acid.
USE: A medicine composition having phospholipase inhibiting action in addition to leukotriene antagonism.
PREPARATION: For example, cyanobenzaldehyde expressed by formula V is reacted with a compound expressed by formula VI to provide a compound expressed by formula VII, which is then hydrolyzed in the presence of a mineral acid to afford the aimed compound expressed by formula I (A is OH).
OGURI TOMEI
SHINODA MAKI
TAKAHASHI KAZUO
HASHIMOTO MUNEHIRO
