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Title:
CARCINOSTATIC AGENT
Document Type and Number:
Japanese Patent JPH03271224
Kind Code:
A
Abstract:

PURPOSE: To obtain a carcinostatic agent, containing dioscin isolated from Dioscorea tokoro Makino of the family Dioscoreaceae as an active ingredient and having powerful inhibitory action on proliferation of cancerous cells with high safety.

CONSTITUTION: A carcinostatic agent containing 3-O-(2-O-α-L-rhamnopyranosyl-4- O-α-rhamnopyranosyl)-β-D-glucopyranosyl-diosgenin (dioscin) expressed by the formula as an active ingredient. The aforementioned compound is obtained by extracting Dioscorea tokoro Makino with water, ethanol or a mixed solvent of water and ethanol, concentrating the resultant extract solution, then purifying the residue by column chromatography in the normal phase system and column chromatography in the reverse phase system, further the column chromatography in the normal phase system and subsequently recrystallizing the prepared substance from methanol.


Inventors:
MURAYAMA MITSUO
OSAWA TAKAOMI
Application Number:
JP1990000063985
Publication Date:
December 03, 1991
Filing Date:
March 16, 1990
Export Citation:
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Assignee:
SANWA SHOYAKU KK
International Classes:
A61K31/58; A61P35/00; C07J17/00; C07J71/00; (IPC1-7): A61K31/58; C07J17/00; C07J71/00