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Patent Searching and Data


Title:
CATECHOLESTROGEN GLYCOSIDE AND ITS USED
Document Type and Number:
Japanese Patent JP3034095
Kind Code:
B2
Abstract:

PURPOSE: To obtain a catecholestrogen glycoside having durable inhibitory action on formation of peroxide lipid, improved water solubility and stability.
CONSTITUTION: A catecholestrogen glycoside of formula I (R1 is H, glucosyl, etc.; R2 is H, glucosyl, etc.; R3 is hydroxyl; R4 is H or ethynyl or R4 and R3 show 0 together; R5 is H or hydroxyl; one of R1 and R2 is glycosyl) such as 1-0-(3-17β-dihydroxy-1,3,5(10)-estratrien-2-yl)-β-D-glucopyranoside. The compound of formula I, for example, is obtained as a desired 2-glucosyl derivative of 2-hydroxy-estradiol by reacting a 2-hydrox yestradiol of formula II protected at the 3- and 17-positions with acetobromoglucose of formula III in the presence of cadmium carbonate and eliminating the protecting group.


Inventors:
Suzuki, Tatsuhiko
Yukimura, Sadaaki
Ishida, Naoko
Oishi, Shigeko
Yagi, Kunio
Application Number:
JP1991000293802
Publication Date:
April 17, 2000
Filing Date:
October 15, 1991
Export Citation:
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Assignee:
Oyo, Seikagaku Kenkyusho
International Classes:
A61K31/56; A61P3/00; A61P3/06; C07J17/00; (IPC1-7): C07J17/00; A61K31/56
Attorney, Agent or Firm:
佐々木 功