To obtain a cathepsin D production facilitative agent which shows high safety to the human body and is useful as a pharmaceutical or cosmetic aiming at preventing and treating dermal disease accompanied with the abnormal abrasion of the corneocyte, skin somberness or ageing.
This cathepsin D production facilitative agent for epidermal cell is obtained by including extracts from at least one kind of plants selected from Catalpa ovata, Schizonepeta tenuifolia var. japonica, Saussurea lappa, Pharbitis nil, Paeonia albiflora, Thea sinensis L., Panax Schinseng, logwood (Haemoloxylum campechianum), Rehmannia glutinosa, thyme(Thymus vulgaris), Prunus persica, Paeonia suffruticosa, Prunus Armeniaca L.var.Ansu, Zingiber officinale, Polygala tenuifolia, Plantago asiatica L., Panax japonicus, Picrasma quassioides, nutgall (Rhus chinensis), Betula platyphylla var.japonica, Cnidium officinale, Coix lacryma-jobi var. ma-guen, Hydrangea macrophylla var. thunbergii, Arnica Montana L., Arctium Lappa L. Litchi chinensis or lily and lactoferrin.
HIGUCHI KAZUHIKO
KITAHARA TAKASHI
KANAZAWA SATOSHI
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