Title:
カチオン性PEG脂質および使用方法。
Document Type and Number:
Japanese Patent JP5117648
Kind Code:
B2
Abstract:
The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention comprise a lipid moiety; a hydrophilic polymer; and a polycationic moiety. Method of increasing intracellular delivery of nucleic acids are also provided.
Inventors:
Chris, Peter Earl.
Chen, Tao
Fenceke, David Bee.
Palmer, Lone Earl.
Won, Kim
Chen, Tao
Fenceke, David Bee.
Palmer, Lone Earl.
Won, Kim
Application Number:
JP2000611949A
Publication Date:
January 16, 2013
Filing Date:
April 20, 2000
Export Citation:
Assignee:
The University of British Columbia
International Classes:
C08G85/00; A61K9/127; A61K31/439; A61K31/7028; A61K31/711; A61K31/7135; A61K38/00; A61K39/00; A61K45/00; A61K47/30; A61K47/34; A61K47/48; A61K48/00; A61K49/00; A61P35/00; A61P37/00; C07K4/00
Domestic Patent References:
JP11507638A | ||||
JP2001504093A | ||||
JP2001503396A |
Foreign References:
WO1998016202A1 | ||||
WO1998016201A1 | ||||
WO1996040285A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto