Title:
Cationic underwater oil type emulsion
Document Type and Number:
Japanese Patent JP6025721
Kind Code:
B2
Abstract:
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.
Inventors:
Burrito, louis
Gir, Andrew
Oh Heagan, Derek
Shin, Manmohan
Gir, Andrew
Oh Heagan, Derek
Shin, Manmohan
Application Number:
JP2013518815A
Publication Date:
November 16, 2016
Filing Date:
July 06, 2011
Export Citation:
Assignee:
Novartis Age
International Classes:
A61K9/107; A61K39/00; A61K47/02; A61K47/10; A61K47/14; A61K47/18; A61K47/24; A61K47/26; A61K47/28; A61K47/34; A61K47/44; A61K48/00; A61P31/00; A61P37/04
Domestic Patent References:
| JP11508231A | ||||
| JP2006321800A | ||||
| JP2002537102A | ||||
| JP2002521423A | ||||
| JP2003535057A | ||||
| JP11507373A | ||||
| JP2005510244A |
Foreign References:
| US20090306194 | ||||
| WO2009127060A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita