Title:
CCNU HOMOLOGUE SUBSTITUTED BY HETEROCYCLIC OR ALKYL RESIDUAL GROUP AND ITS MANUFACTURE
Document Type and Number:
Japanese Patent JPS5557552
Kind Code:
A
Abstract:
This invention relates to compounds having the formula: wherein R1 and R2 are selected from the group consisting of hydrogen, acyl, trifluoroacetyl, straight chained and branched alkyl groups with up to 6 carbon atoms, such alkyl groups with up to 3 substituents selected from the group consisting of OH, OSO2CH3, COOH, COOR, CONH2 and Hal, where R is an alkyl group with up to 6 carbon atoms, and R1 and R2 together form a heterocyclic ring containing 4 to 6 carbon atoms and optionally further heteroatoms and such rings with up to 3 substituents selected from the group consisting of lower alkyl, OH, COOH, COOR, CONH2, where R has the above meaning, the chloroethyl nitrosoureido group and Hal, and Hal is selected from the group consisting of chlorine and fluorine, which heterocyclic ring is not the para-methyl piperazine group, said nitroso ureas having a tumor inhibiting effect. This invention also related to a method of inhibiting transplanted tumors which comprises treating a tumor-afflicted subject with one of the foregoing 1,3 - disubstituted nitroso ureas. It also involves a method of preparing such new compounds by reacting N-(2-halogenethyl)-N-nitrosocarbamoylazide with hydrazine or a monocyclic N-amino heterocyclic or their derivatives.
Inventors:
GERUHARUTO AIZENBURANTO
Application Number:
JP13469879A
Publication Date:
April 28, 1980
Filing Date:
October 17, 1979
Export Citation:
Assignee:
DEUTSCHES KREBSFORSCH
International Classes:
A61K31/395; A61P35/00; C07C67/00; C07C239/00; C07C291/02; A61K31/175; C07D265/30; C07D295/22; C07D295/28; (IPC1-7): A61K31/175; A61K31/395; C07C133/00; C07D265/30; C07D295/22