CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF

Japanese Patent JP2023058027

A

To provide variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides for providing therapeutic utility to a variety of immunological and oncological conditions, and nucleic acids encoding such proteins, as well as compositions and methods for preparing and using such proteins.SOLUTION: Provided is a variant CD80 polypeptide comprising an IgV domain or a specific binding fragment thereof, or an IgC domain or a specific binding domain thereof or both, where the variant polypeptide comprises one or more amino acid modifications at one or more positions relative to an unmodified CD80 or specific binding domain thereof, corresponding to the certain sequence, where the number of modified amino acids is not more than 14.SELECTED DRAWING: Figure 3A

Swanson Ryan
Cornucker Michael
Maurer Mark F.
Ardorel Dan
Demonte Daniel William
Kaupper Joseph El.

JP2022163426A

April 24, 2023

October 11, 2022

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Alpine Immun Sciences Incorporated

C12N15/12; A61K35/74; A61K35/76; A61K38/02; A61K39/395; A61K47/62; A61K47/68; A61K48/00; A61P35/00; A61P35/02; A61P37/02; C07K14/705; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01; C12N15/62; C12N15/63; C12P21/02; G01N33/53; G01N33/536; G01N33/543

Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto

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