Title:
CELL OF CARDIOMYOCYTE LINEAGE PRODUCED FROM HUMAN PLURIPOTENT STEM CELL
Document Type and Number:
Japanese Patent JP2011050385
Kind Code:
A
Abstract:
To provides human cell populations of the cardiomyocyte lineage.
The cells are obtained by causing cultures of pluripotent stem cells to differentiate in vitro, and then harvesting cells with certain phenotypic features. Differentiated cells bear cell surface and morphologic markers characteristic of cardiomyocytes, and a proportion of them undergo spontaneous periodic contraction. Highly enriched populations of cardiomyocytes and their replicating precursor cells, suitable for a variety of applications, such as drug screening and therapy for cardiac disease, can be obtained.
Inventors:
XU CHUNHUI
Application Number:
JP2010219095A
Publication Date:
March 17, 2011
Filing Date:
September 29, 2010
Export Citation:
Assignee:
GERON CORP
International Classes:
C12N5/0735; C12N15/09; A61K35/28; A61K35/34; A61K35/54; A61P9/00; A61P9/10; C12N5/02; C12N5/077; C12N5/10; C12Q1/02; A61K35/12
Foreign References:
| WO2001048151A1 | 2001-07-05 | |||
| WO1999053021A1 | 1999-10-21 |
Other References:
JPN6012046535; Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．ＳＣｉ．ＵＳＡ Ｖｏｌ．９７， Ｎｏ．２１, 2000, ｐ．１１３０７-１１３１２
JPN6012046538; Ｄｅｖ．Ｂｉｏｌ． Ｖｏｌ．２２７, 2000, ｐ．１３３-１４５
JPN6011010319; 血液・免疫・腫瘍 Ｖｏｌ．５， Ｎｏ．４, 2000, ｐ．３５-３８
JPN6012046540; Ｊ．Ｃｅｌｌ．Ｐｈｙｓｉｏｌ． Ｖｏｌ．１６８, 1996, ｐ．４２-５０
JPN6012046543; Ｊ．Ｍｏｌｌ．Ｃｅｌｌ．Ｃａｒｄｉｏｌ． Ｖｏｌ．２３, 1991, ｐ．１６１-１７３
JPN6012046538; Ｄｅｖ．Ｂｉｏｌ． Ｖｏｌ．２２７, 2000, ｐ．１３３-１４５
JPN6011010319; 血液・免疫・腫瘍 Ｖｏｌ．５， Ｎｏ．４, 2000, ｐ．３５-３８
JPN6012046540; Ｊ．Ｃｅｌｌ．Ｐｈｙｓｉｏｌ． Ｖｏｌ．１６８, 1996, ｐ．４２-５０
JPN6012046543; Ｊ．Ｍｏｌｌ．Ｃｅｌｌ．Ｃａｒｄｉｏｌ． Ｖｏｌ．２３, 1991, ｐ．１６１-１７３
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto
Toshi Gobe
Koichi Niimi
Kazuya Kawamoto