Title:
シアリダーゼの同定および画像化のための細胞透過性プローブ
Document Type and Number:
Japanese Patent JP6302909
Kind Code:
B2
Abstract:
Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.
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Inventors:
Won, Qi-Hui
Fan, jin-min
Chen, Yi-Shun Yi.
Tsai, Chang-Shen
Fan, jin-min
Chen, Yi-Shun Yi.
Tsai, Chang-Shen
Application Number:
JP2015527678A
Publication Date:
March 28, 2018
Filing Date:
August 16, 2013
Export Citation:
Assignee:
ACADEMIA SINICA
International Classes:
C07H7/033; C07H15/26; C12Q1/04; C12Q1/34; G01N33/566; G01N33/573
Domestic Patent References:
| JP63218688A |
Foreign References:
| WO2011006237A1 | ||||
| WO2010029302A2 |
Other References:
Carbohydrate Research,2004年,Vol.339, No.7,pp.1367-1372
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto