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Title:
細胞および血清タンパク質アンカー並びに接合体
Document Type and Number:
Japanese Patent JP3983799
Kind Code:
B2
Abstract:
Novel bifunctional reagents useful in providing extended in vivo lifetimes of physiologically active agents are provided. The reagents comprise conjugates of a first binding member specific for a target in a mammalian host, such as a toxin, drug of abuse, microbe, autoreactive immune cell, infected or tumourous cell, antigen presenting cell, or the like, joined to a second binding member specific for a long-lived blood component, including cells, such as an erythrocyte, platelet or endothelial cell, and plasma proteins. These conjugates find use by extending the lifetime and availability of the target binding member for coupling the target and the blood component and thereby reducing the concentration free target, modulating the volume of distribution of the target, targeting the target to sites of enhanced immune response, facilitating target clearance from the bloodstream, or extending the stimulation of an immunogen.

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Inventors:
Pauletti, Philip
Pauletti, Christine
Application Number:
JP51106295A
Publication Date:
September 26, 2007
Filing Date:
September 16, 1994
Export Citation:
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Assignee:
Konjuchem Biotechnology Inc.
International Classes:
A61K38/00; A61K38/16; A61K39/385; A61K39/395; A61K45/00; A61K47/48; A61P43/00; C07K14/16; C07K14/73; C07K16/08; C07K16/16; C07K16/28; C07K16/34; C07K16/44; C07K16/46
Domestic Patent References:
JP3200763A
Foreign References:
WO1991001743A1
GB2218100A
DE4014540A1
Other References:
THE JOURNAL OF IMMUNOLOGY,1992,Vol.148,No.8,p.2462-2468
FEBS LETTER,1983,Vol.154,No.2,p.257-261
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY,1992,No.16,p.188-194
Journal of Acquired Immune Deficiency Syndromes,1990,Vol.3,No.11,p.1041-1045
THE JOURNAL OF IMMUNOLOGY,1987,Vol.139,No.9,p.3153-3158
Proc.Natl.Acad.Sci.USA,1991,Vol.88,p.3305-3309
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe



 
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