Title:
細胞移植用細胞構造体、生体親和性高分子ブロック及びそれらの製造方法
Document Type and Number:
Japanese Patent JP6506326
Kind Code:
B2
Abstract:
It is an object of the present invention to provide a cell construct for cell transplantation that does not contain a substance having cytotoxicity, such as glutaraldehyde, and suppresses the necrosis of the transplanted cells in the construct (namely, having a high cell survival rate). The present invention provides a cell construct for cell transplantation comprising biocompatible polymer blocks that do not contain glutaraldehyde and at least one type of cells, wherein a plurality of biocompatible polymer blocks are disposed in gaps among a plurality of cells, and wherein the biocompatible polymer blocks have a tap density of 10 mg/cm 3 or more and 500 mg/cm 3 or less, or the value of the square root of the cross-sectional area / boundary length in the two-dimensional sectional image of the polymer block is 0.01 or more and 0.13 or less.
Inventors:
Kentaro Nakamura
Iwasawa Reiko
Hayato Miyoshi
Yudai Yamaguchi
Fushimi Hideo
Iwasawa Reiko
Hayato Miyoshi
Yudai Yamaguchi
Fushimi Hideo
Application Number:
JP2017028860A
Publication Date:
April 24, 2019
Filing Date:
February 20, 2017
Export Citation:
Assignee:
FUJIFILM Corporation
International Classes:
A61L27/22; A61K35/12; A61L27/24; A61L27/38; A61L27/56; C07K14/78; C12N11/02
Domestic Patent References:
| JP2010083788A | ||||
| JP62026230A |
Foreign References:
| WO2011108517A1 |
Other References:
人工臓器,1993年,Vol.22,No.2,p364-369
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes