Title:
血管形成阻害の標的としての細胞表面トロポミオシン
Document Type and Number:
Japanese Patent JP2006501139
Kind Code:
A
Abstract:
The present invention is directed to novel methods for inhibiting angiogenesis and treating tumors and cancer by targeting tropomyosin (Tpm) expressed on the surface of endothelial cells and/or tumor cells, to Tpm polypeptides and peptides, as well as variants and derivatives thereof that bind inhibitors of angiogenesis, and to anti-Tpm antibodies that block or stimulate angiogenesis. Cyclic peptides that bind to the D5 subunit of HKa and inhibit angiogenesis are also included. Method for screening test compounds as candidate antiangiogenic molecule that binds to Tpm are disclosed, as are affinity ligands comprising the proteins, peptides, variants and derivatives of the invention.
More Like This:
Inventors:
McCrea, Keith
Donate, Fernando
Jose, jose
Mother, Andrew P.
Donate, Fernando
Jose, jose
Mother, Andrew P.
Application Number:
JP2003575926A
Publication Date:
January 12, 2006
Filing Date:
March 17, 2003
Export Citation:
Assignee:
Athenon, LRC
International Classes:
C07K14/78; A61K38/12; A61K38/17; A61K39/395; A61K45/00; A61K47/02; A61K47/48; A61K51/00; A61P9/00; A61P17/06; A61P19/02; A61P27/02; A61P27/06; A61P35/00; A61P35/04; C07K7/64; C07K14/47; C07K14/475; C07K14/705; C07K16/18; C07K16/28; C07K16/30; C12N5/07; C12N5/09; C12N15/09; C12Q1/02; G01N33/15; G01N33/50; G01N33/53; G01N33/68; A61K38/00; C12P21/08
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita