Title:
CELL THERAPY FORMULATION METHOD AND COMPOSITION
Document Type and Number:
Japanese Patent JP2012021033
Kind Code:
A
Abstract:
To provide a method for formulating an ex vivo-prepared T-cell for infusion.
The ex vivo-prepared T-cells are harvested from cell culture conditions and formulated in a medium suitable for infusion. The formulation is made by labeling the cells with one or more factors which have reactivity for T-cell surface moieties deliverable of activation signals upon cross-linking, and mixing the labeled cells with biodegradable nanospheres or microspheres coated with a material cross-linkable of the agents attached to the T-cell surface moieties. Alternatively, the formulation may be made by mixing a population of T-cells with biodegradable nanospheres or microspheres coated with a first material and one or more second materials.
Inventors:
HAR-NOY MICHAEL
Application Number:
JP2011236442A
Publication Date:
February 02, 2012
Filing Date:
October 27, 2011
Export Citation:
Assignee:
IMMUNOVATIVE THERAPIES LTD
International Classes:
A61K35/14; A61K9/10; A61K9/50; A61K9/51; A61K47/34; A61P31/04; A61P31/12; A61P35/00; A61P37/04; C12N5/0783; A61K39/00
Domestic Patent References:
| JPH08511166A | 1996-11-26 |
Foreign References:
| WO2003024989A2 | 2003-03-27 | |||
| WO1994012196A1 | 1994-06-09 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita