Title:
セルロース系イオン交換膜及びその製造方法、エキソソーム精製用のデバイス、並びにエキソソームの精製方法
Document Type and Number:
Japanese Patent JP7384278
Kind Code:
B2
Abstract:
An object of the present invention is to provide an ion-exchange membrane for simply and inexpensively separating and purifying exosomes present in a biological sample such as serum. The invention relates to a cellulose-based ion-exchange membrane containing a cellulose-based polymer having at least one hydroxyl group or acetyl group at the 2-, 3-, or 6-position being replaced with a positively charged compound. The invention also relates to a method for purifying exosomes, including subjecting a sample containing exosomes to membrane permeation by using the cellulose-based ion-exchange membrane to allow for adsorption of the exosomes, bringing the membrane into contact with a washing liquid to remove impurities, and bringing the membrane into contact with an eluent to allow for desorption of the exosomes.
Inventors:
Ayano Higaki
Hirofumi Hakuba
Hirofumi Hakuba
Application Number:
JP2022517116A
Publication Date:
November 21, 2023
Filing Date:
April 23, 2021
Export Citation:
Assignee:
Toyobo Co., Ltd.
International Classes:
C08J5/22; C12M1/00; C12M1/26; C12M3/06; C12N5/00; G01N33/50
Domestic Patent References:
| JP2019527617A | ||||
| JP8503161A |
Foreign References:
| WO2017154951A1 |
Attorney, Agent or Firm:
Saegusa International Patent Office
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