Title:
CEPHALOSPOLINE SYSTMEM COMPOUNDS AND PROCESS FOR PREPARING SAME
Document Type and Number:
Japanese Patent JPS5387391
Kind Code:
A
Abstract:
The compounds correspond to the formula: in which R denotes phenyl, thienyl or furyl, and Y denotes a group S(O)nR<1>, OR<3>, OCOR<4> or OCOAR<5>, and R<1>, R<3>, R<4>, R <8 > , A, n and the other symbols have the meanings given in Claim 1. The preparation is effected by reacting a 3-Ymethyl-7-aminoceph-2- or 3-em-4-carboxylic acid, whose carboxyl group can be blocked, or a corresponding salt or N-silyl derivative, with a carboxylic acid corresponding to the left hand part of the above formula, or with an acylating agent derived from this carboxylic acid, after which there is at most elimination of a carboxyl-blocking group. If the product is not obtained as a pure syn isomer, or with a content of at least 75 % thereof, an isomeric separation follows. In addition, the carboxylic acids can be esterified, 3-acyloxymethyl compounds can be deacylated to give 3-hydroxymethyl compounds, and 3-hydroxymethyl compounds can be acylated or carbamoylated. The compounds are antibiotics possessing a broad spectrum of activity; they are resistant to beta -lactamase and active, inter alia, against certain Enterobacteriaceae.
Inventors:
MAIKERU UORUTAA FUOTSUKUSUTON
GOODON IAN GUREGORII
DEIBITSUDO MARUKOMU ROJIYAAZU
UIRIAMU KINGUSUTON WAABAATON
ADORIAN JIYON PAIPU
GOODON IAN GUREGORII
DEIBITSUDO MARUKOMU ROJIYAAZU
UIRIAMU KINGUSUTON WAABAATON
ADORIAN JIYON PAIPU
Application Number:
JP14378377A
Publication Date:
August 01, 1978
Filing Date:
November 29, 1977
Export Citation:
Assignee:
GLAXO LAB LTD
International Classes:
C07D501/32; A61K31/545; A61K31/546; A61P31/04; C07D307/54; C07D501/24; C07D501/26; C07D501/34; C07D501/36; (IPC1-7): A61K31/545; C07D501/32; C07D501/34; C07D501/36