NEW MATERIAL:A compound of formula I: (X is NH2, N3, or phthalimino group; R1 is H, halogen, lower alkoxy group, etc,; R2 is R1, lower alkyl, N3, etc,; R3 is H, alkyl, aryl group, etc.), and its salt.
EXAMPLE: (±)Cis,2-tert-butyloxycarbonyl-7-azido-1-azabicyclo[4,2,0]oct-2-ene- 8-one.
USE: An intermediate for the synthesis of antibacterials capable of giving powerful antibacterials by introducing various acyl groups into the 7-postion.
PROCESS: A compound of formula II: (R21 is H or lower alkyl group) is reacted with a compound of formula III: (R31 is alkyl, aryl group, etc.), and the reaction product is them reacted with an active derivative of the formula X1CH2COOH (X1 is N3 or phthalylimino group) to give a compound of formula IV, which is then reacted with O3, etc., and subjected to the Horner-Wittig reaction to give the objective compound of formula V.
OGASA TAKEHIRO
SAITOU HIROMITSU
NAKAMIZO YOSHIHIRO
