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Title:
CEPHALOSPORIN ANALOG
Document Type and Number:
Japanese Patent JPS54128591
Kind Code:
A
Abstract:

NEW MATERIAL:A compound of formula I: (X is NH2, N3, or phthalimino group; R1 is H, halogen, lower alkoxy group, etc,; R2 is R1, lower alkyl, N3, etc,; R3 is H, alkyl, aryl group, etc.), and its salt.

EXAMPLE: (±)Cis,2-tert-butyloxycarbonyl-7-azido-1-azabicyclo[4,2,0]oct-2-ene- 8-one.

USE: An intermediate for the synthesis of antibacterials capable of giving powerful antibacterials by introducing various acyl groups into the 7-postion.

PROCESS: A compound of formula II: (R21 is H or lower alkyl group) is reacted with a compound of formula III: (R31 is alkyl, aryl group, etc.), and the reaction product is them reacted with an active derivative of the formula X1CH2COOH (X1 is N3 or phthalylimino group) to give a compound of formula IV, which is then reacted with O3, etc., and subjected to the Horner-Wittig reaction to give the objective compound of formula V.


Inventors:
HIRATA TADASHI
OGASA TAKEHIRO
SAITOU HIROMITSU
NAKAMIZO YOSHIHIRO
Application Number:
JP1978000034696
Publication Date:
October 05, 1979
Filing Date:
March 25, 1978
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO KK
International Classes:
A61K31/435; A61K31/655; A61P31/04; C07D463/00; C07F9/568; (IPC1-7): A61K31/435; A61K31/655; C07D471/04