Title:
CEPHALOSPORIN COMPOUND AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPS6456682
Kind Code:
A
Abstract:
NEW MATERIAL:The compound of formula I (R1 and R5 are H or amino- protecting group; R2 is alkyl or cycloalkyl; R3 is H, lower alkenyl, alkanoyloxymethyl, carbamoyloxymethyl, heterocyclic-thiomethyl or heterocyclic- methyl; R4 is H or ester residue; X is CH or N) and its addition salt.
EXAMPLE: 7-[2-(2-Aminothiazol-4-yl) 2-( 2-amino-1-methylethoxyimino )acetami do]-3-(1,3,4-thiadiazol-2-yl) thiomethyl-3-cephem-4-carboxylic acid dihydrochloride (syn isomer).
USE: Antibacterial agent against Pseudomonas genus bacteria, Gram-positive bacteria, Gram-negative bacteria, etc.
PREPARATION: A 7-aminocephalosporanic acid compound of formula II is made to react with a carboxylic acid compound of formula III or its reactive deriva tive.
Inventors:
NISHIZAWA SUSUMU
MURO HIROYUKI
KASAI MASAYASU
HATANO SATORU
KAMIYA NAOHARU
KAKEYA SENJI
KITAO KAZUHIKO
MURO HIROYUKI
KASAI MASAYASU
HATANO SATORU
KAMIYA NAOHARU
KAKEYA SENJI
KITAO KAZUHIKO
Application Number:
JP9853988A
Publication Date:
March 03, 1989
Filing Date:
April 20, 1988
Export Citation:
Assignee:
KYOTO PHARMA IND
International Classes:
C07D501/20; A61K31/545; A61K31/546; A61P31/04; C07D501/22; C07D501/34; C07D501/36; C07D501/56; C07D501/59; (IPC1-7): A61K31/545; C07D501/20; C07D501/22; C07D501/34; C07D501/36; C07D501/56; C07D501/59
Attorney, Agent or Firm:
Takashima Hajime