To obtain a new cephalosporin derivative having a strong and wide range antimicrobial activities, excellent in peroral absorption characteristics and useful as an antibiotic agent for preventing and curing infectious diseases.
This new cephalosporin derivative is a compound expressed by formula I (R1 is hydroxyphenyl, 3-nitrophenyl, 3-fluoro-4-hydroxyphenyl, 4-aminobenzyl, etc.), its ester, its salt or its hydrate, e.g. (6R, 7R)-7-[(Z)-2-(2- aminothiazol-4-y1)-2-hydroxyimino-acetylamino]-3-[(E)-1-(4-hydroxyphenyl)-2 oxopyrrolidin-3-ylidenemethyl]-8-oxop5-thia-1-azacyclo[4.2.0]octa-2-ene-2- carboxylic acid. The compound of formula I is obtained by reacting a compound of formula II (Rh is H) with a compound of formula III (R2 is H or a OH- protecting group; R3 is an activated group of OH, etc.; Rf is H or an amino- protecting group) and, if necessary, removing the protecting groups.
INGURITSUTO HAINTSUUKURAUSU
HANSU RIHITAA
BUARERI RANTSU
HENRI SUTARUDAA
URUSU BUAISU
JIYOOJI PETOROSU YANNIKOUROSU
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