Title:
CEPHALOSPORIN ISOQUINOLINIUM BETAINES
Document Type and Number:
Japanese Patent JPS5857386
Kind Code:
A
Abstract:
Broad spectrum cephalosporin betaine antibiotics represented by the formula wherein R' is a heterocyclic ring, e.g. 2-aminothiazol-4-yl, 2-amino-1,3,5-thiadiazol-4-yl, or 2-aminopyridin-6-yl; R'' is C1-C4 alkyl, especially methyl, a substituted carbamoyl group, or a carboxy-substituted alkyl or cycloalkyl group; and R1 is isoquinolinium or a substituted isoquinolinium group are provided. Compounds wherein R1 is isoquinolinium are preferred especially syn-7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-(isoquinolin ium-2-ylmethyl)-3-cephem-4-carboxylate. Pharmaceutical formulations and a method for treating infectious diseases comprising the use of the antibiotics are described.
Inventors:
UIRIAMU EICHI DABURIYUU RAN
JIYOON KEI SHIEIDORU
JIYOON KEI SHIEIDORU
Application Number:
JP15797282A
Publication Date:
April 05, 1983
Filing Date:
September 08, 1982
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
A61K31/545; A61K31/546; A61P31/04; C07D501/16; C07D501/18; C07D501/20; C07D501/38; C07D501/42; C07D501/44; C07D501/46; C07D501/56; A61K; C07D; (IPC1-7): A61K31/545; C07D501/18; C07D501/46
Attorney, Agent or Firm:
Mitsutaka Iwasaki